On my 4S it seems like Safari has a little bug sometimes going between landscape and portrait, not a showstopper. Sometimes to get it to go landscape I have to turn it back to portrait and then back to landscape.
Some things are a little slower for me, it seems more so in the OS software than third-party apps, but again not a showstopper IMO.
If I understand correctly (not a guarantee at my age), iPhoto is replaced by Photos? I read that a lot of people are having trouble with the transition. Some people say they can no longer post pictures from the iPad to a forum.
May the (mass times acceleration) be with you.
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