I installed it on my MacBook tonight, since that isn't my main machine, and because I couldn't take any chances on my main machine because I'm taking three online courses while working full time.
The only deal breakers so far are the loss of PowerPoint (Office 2004) and Toast 6 Titanium. I even installed Rosetta, which got the older Adobe apps running again, but those two apps are dead in the water and I need both of them. I sent the crash reports to Apple, not that it will do any good. Both of those apps are old, and I don't use them all that often, but I need to have them around, even though I can't afford to upgrade them.
Even Photoshop CS works fine. No problems at all with either Adobe apps or the old Macromedia apps that I had installed. Only problems I ran into was with ImageWell (the old, free version), PowerPoint (any version), and Toast Titanium 6 (I know it's old, but I rarely use it, so don't want to buy a newer version). Otherwise, all is dandy. I'm still gonna wait to install it on the Mac Pro, but only because I'm in the middle of a semester of accelerated online courses and can't afford any hiccups right now. Back to the books!
Edit: Oooops, I forgot to mention that it also broke Keynote (3.0.2), which was my only substitution for PowerPoint! Big ouch! I'll have to try NeoOffice when I have some spare time.
ImageWell = Skitch It doesn't have quite as many options as IW, but it's a much more polished app (I hate to say it, sorry Hagan!) Plus, you get free online hosting of your images, as well as an "archive" or "history" of the images you've uploaded built right into the app.
Toast Titanium 6 = Apple's Disk Utility or any number of free burning apps. Do a search at MacUpdate and you'll find a bunch
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