I'm also having a slow launch for 10.0.4 on both my machines. My iMac is running the latest system upgrade, but my laptop is not and the same thing is happening. So I don't think it's the system upgrade.
What's happening as I write on my MacBook Pro is that the calendar launches quickly and the menus follow later, several minutes later. I can make changes to the calendar even as I wait for the menus to become active again and I can move between the calendar and the contact list.
So I think it's something in the version of Now X which creates a pressure to find an alternative. After reading all the posts on the subject so far, I think I'm going to try the Chronos product first. My needs are pretty simple and their description, plus the more reasonable cost, seem to fit my needs.
Daniel
Whoops! Now the whole thing is grayed out and I can't do anything! Can't even get the menus to show at all. So I took a break and when I returned about 10 minutes later, everything was fine.