Yes, you would lose a port, but if you used a 4 port hub, you'd still be up 3. If you did decide to make an internal keyboard/mouse dongle, you'd be up 2 ports. Yes, the range may be limited due to being inside the powerbook, but range is fairly limited with those anyway. You may only have to be 8 feet away instead of 10. And you can get a digitizer from ebay for about $80-100.