I have not tried to boot from a CD we image all of our computers! I put the new 7200 RPM 80GB HD in to the computer and target booted it installed the image fine and then restarted it and it shows the "?" like it can not see the HD. I tried this with 3 new out of the box HDs. I then found a used 5400 RPM 40GB HD like what came out of the computer and installed it and imaged it the same as the others! This time it started fine and runs with no problem. My problem is I am having a hard time finding 5400 RPM HDs and I need to use the 7200 RPM HDs if I can get them to work some how.