Anything is possible. The hardest part to overcome would be that the Wii is 1/4" thinner than a Mini. I haven't been into a mini, but I'd be surprised if there's that much extra clearance. Other than that, there's about 2" extra in length and width. Those 2" would make port relocation easy enough. Perhaps you could even integrate the SD card reader in the front.
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"Far better it is to dare mighty things than to take rank with those poor timid spirits who know neither victory nor defeat." - Theodore Roosevelt

-USMC Corporal Hess Sherrod B:6/6/84 D:4/6/09 I miss you, my brother.