What do you mean? As in upgradeing the board to use a diffrent chipset? If thats the case then don't bother with it because it will not work and if it does work it won't work very well. You can although put in more memory on it by finding some compatable memory chips and desolder the old ones and put on the new ones.
Have to remember the BIOS/Frimware is diffrent with each GPU chipset unless you can find a GPU that is the same model but has a faster clock. So say you have a ATI Readon 7000 and you want to change it to a ATI 9800 then you would have to change the BIOS/Frimware.
To live is to let die