The zip bay will accomodate a 3.5 inch drive, however it is possible to dremel the aluminum and create a support structure inside to house a 5.25" drive. I have run a hard drive in that slot before (note to self, next time don't fry the drive by not ventilating properly). The extra power and IDE cable is all set up for you. All you need to do is make room. It's very simple, but I haven't seen it done. You may be the first. Can you take pics and make it a guide for others?
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