Sure can. <br><br>I had this for a few days...had to take it back 'cause I didn't like it. Nice keyboard though. <br><br>As I recall, you have to go into the software and disable whatever shortcut they have assigned to that key, and it's not by key number. Look for "cut", "copy" "paste" and so on. It's a headache, but it can be programmed to all work just the way you want it to. Same with Expose and Dashboard. <br><br>